Utilize 80 million years of evolutionary data to transform your understanding of genetic variations and improve human health.
CodeXome integrates advanced evolutionary insights with modern human genomic studies. Reclassify genetic variants, predict protein function, and discover therapeutic targets with unmatched precision.
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Datasets generated from proprietary cell lines, including those of endangered primate taxa, provide a unique resource not available elsewhere to support robust cross-species comparisons.
Researchers have reclassified over 30% of BRCA1 Variants of Uncertain Significance (VUS) with CodeXome's evolutionary insights, turning ambiguity into clarity and enhancing diagnostic accuracy.
Integrates data from over 55 primate genera, enabling researchers to see evolutionary patterns and reclassify variants based on high-confidence evolutionary markers.
Traditional genomic studies often suffer from population biases. CodeXome eliminates these biases with a population-agnostic approach based on evolutionary history, providing clearer and more accurate insights.
Many genetic variants remain classified as uncertain due to limited context. CodeXome uses evolutionary data to reclassify these variants, reducing ambiguity and enhancing diagnostic accuracy.
Traditional methods may miss how genetic changes impact protein function. CodeXome’s evolutionary analysis predicts these effects, offering insights into biological significance.
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CodeXome’s evolutionary analysis has provided groundbreaking insights into how genetic changes influence stress responses in humans, with a focus on Post-Traumatic Stress Disorder (PTSD).
ADCYAP1, a neuroendocrine gene critical for stress response, has shown unique evolutionary changes in humans compared to other primates. These changes are linked to critical functional domains that regulate neuropeptide activity.
Using CodeXome, we identified that ADCYAP1 has undergone specific amino acid substitutions in humans, particularly in regions known as Intrinsically Disordered Regions (IDRs). These regions play a vital role in neuropeptide transport and signaling in the central nervous system.
This evolutionary insight provides a new understanding of how human stress responses have evolved, pointing to new therapeutic targets for treating PTSD and other neurological disorders. The findings suggest that targeted modulation of these IDRs could influence the effectiveness of treatments for stress-related conditions.
Traditional methods of variant classification often leave many questions unanswered, with numerous genetic variants categorized as uncertain. CodeXome’s approach changes this by providing a broader evolutionary context, leading to more accurate and reliable classifications.
CodeXome integrates evolutionary data from a wide range of primate genera, providing a more meaningful interpretation of genetic variants than traditional population-based methods.
Focuses on evolutionary history rather than modern population constraints, offering insights that transcend current human genetic boundaries.
Provides real-time reclassification of genetic variants using current evolutionary data, ensuring the most accurate information for research and clinical decisions.
CodeXome examines the broader evolutionary story of genes and proteins, not just variant identification, offering a holistic view of genetic function.
Presents clear, accurate representations of genetic variations across relevant primate genera, avoiding the incomplete interpretations of less comprehensive approaches.
Moves beyond the traditional focus on population-based analysis, prioritizing evolutionary insights to deliver groundbreaking findings.
Upload Variant Call Format (VCF) files from individual patients or cohorts to the secure CodeXome cloud. Data is aligned with the human reference genome (HG38) and CodeXome’s dataset of 55 primate genera.
The platform cross-references uploaded data with major genomic databases like gnomAD, UniProt, and ClinVar, alongside CodeXome’s proprietary evolutionary datasets, ensuring comprehensive analysis.
Utilizing evolutionary data, CodeXome reclassifies Variants of Uncertain Significance (VUS), providing real-time, updated variant interpretations with greater confidence.
Analyze the evolutionary history of variants to predict their impact on protein function, identifying changes that may be benign, pathogenic, or therapeutically significant.
Get started with our CodeXome Preview to see a glimpse of how our database can further your genetic efforts and request full access to the platform.
Try a Gene in CodeXome Preview
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